The issues of strength, stability, effective projecting of an elastic plate taking into account the reaction to the seismic impact are confronted in the engineering constructions. In modern structures, elastic isotropic and anisotropic plates, which are under influence of forces, have practical applications.  Determine the optimal parameters of the location of the transverse piers along the length of the rectangular orthotropic piecewise-homogeneous plate, when the plate between and outside the piers is constructed from orthotropic materials with different elastic modules ensuring the minimum value of the maximum bending of plate. Based on the results obtained, it is possible to significantly reduce the weight of elements of thin-walled structures, as well as save materials and energy.